Lockettes are popularly believed to have lower rates of individuals who are transgender than organic species, due to the fact saura tends to cause changes to the shell it chooses to inhabit.  Actual research, however, suggests that lockettes may have higher incidences of transgender individuals than other species.  In a theoretically immortal life, it is not all that unusual for an individual to decide they wish to be a different gender entirely, or to have different genitalia than what they had before.

In fact, shells make it quite easy for any lockette to experiment with their body parts, if they’re willing to fragment themselves a little bit.  Prosthetic breasts, penises, vulvas and vaginas, tentacles, knots, and more are sold right alongside more ‘typical’ prosthetics such as arms and legs.  (There are even little arms shaped to be attached to the groin, for those who want an extra hand).

There is little research on how many lockettes manifest in a way that would be considered intersex, but it can be inferred that numbers are likely higher than for organic species.  Other lockettes may become intersex by choice.

Sexuality has historically had a similarly broad spectrum of accepted identities.

While some groups of humans did attempt - both consciously and unconsciously - to instill biases based on gender and sexuality into the lockettes they encountered, such attempts were generally fruitless.  There may be some individuals who took on those beliefs, but it is quite uncommon and most lockettes disapprove of those who follow human beliefs.